

Oesophageal cancer is one of the most common malignancies worldwide. Its mortality is very high due to relatively late diagnosis and inefficient treatment. The ability to reverse the outcome of oesophageal cancer is limited due to a poor understanding of its biology. Progression of oesophageal cancer may be associated with sphingosine 1-phosphate (S1P) and its receptors S1P1-5, which play an important role in other cancers. A possible role for S1P and its receptors in human oesophageal cells has not previously been investigated, nor has the importance of S1P and its receptors in oesophageal cancer growth and metastasis been addressed.
Using semi-quantitative reverse transcription polymerase chain reaction, gene transfection, MTT assay and transwell migration assay, a research team from China investigated S1P receptor expression profile in human oesophageal cancer cells and the effects of S1P5 on proliferation and migration. Their study will be published on April 21, 2010 in the World Journal of Gastroenterology.
They found S1P binding to S1P5 inhibits the proliferation and migration of S1P5-transfected Eca109 cells.
Their results indicated that deficiency in inhibitory effect of S1P-S1P5 may be of importance in the growth and metastasis of oesophageal cancer. S1P5 or its associated signalling molecules may serve as a future strategy in biotherapy for oesophageal cancer.
Inherited risk factors increase odds of developing childhood acute lymphoblastic leukaemia
Scientists create energy-burning brown fat in mice
Genome of parasitic flatworm that causes schistosomiasis decoded
MTV survey cranks up the volume on loud music's impact on hearing