



An Oregon Health and Science University researcher believes the discovery of a gene cluster from a bacterium that protects a moss-like marine invertebrate from predators may be the first step toward engineering cancer-fighting drugs. Margo Haygood, PhD, professor of environmental and biomolecular systems at OHSUs OGI School of Scienceand Engineering, has detailed her research teams discovery of the large gene cluster in a bacterium that protects the larvae of the bushy marine bryozoan Bugula neritina. The bacterium, Endobugula sertula, acting as a symbiont to its bryozoan host, secretes a bioactive molecule that makes the poppy seed-sized larvae distasteful to predatory fish. But that molecule, known as a bryostatin, also confounds a variety of cancer cell lines…
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