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Common congenital defect a prickly problem for the kidney

Science Centric (22 Feb 2011 23:32 GMT) - One of the most common congenital defects in humans - it is detected in approximately 0.5% of foetuses analysed by routine antenatal sonography - is a kidney abnormality known as hydronephrosis. Hydronephrosis arises because the flow of urine from the kidney to the bladder is impeded. By studying kidney development in mice, Norman Rosenblum and colleagues, at the Hospital for Sick Children, Toronto, have identified a new cellular mechanism underlying hydronephrosis, something that they hope might lead to better therapeutics for the condition and improved diagnosis of its severity…

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