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Researchers pinpoint when a cell is ready to reproduce

A budding interest. As they replicate, yeast cells form buds that grow and eventually separate from their mother cells. The appearance and disappearance of a green fluorescent protein at the bud neck indicates how long mother and daughter cells spend in G1, the first phase of the cell cycle (c) The Rockefeller University

Tags: cell, cellular, molecular, yeast

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— 22 September 2007 13:39 GMT | Biology

For more than 100 years, scientists have tried to figure out the cell size problem: How does a cell know when it is big enough to divide? In research conducted in budding yeast (Saccharomyces cerevisiae), scientists at Rockefeller University have now identified the cellular event that marks the moment when a cell knows it is big enough to commit to cell division and spawn genetic replicas of itself. The findings, reported in the 23 August issue of the journal Nature, provide a precise and quantitative framework for studying the possible mechanisms that allow cells to monitor and sense their size... — full story