Journal of Clinical Investigation
http://www.jci.org/
Gag order: how DNA silencing can promote cancer
— 2 Apr 2011 11:40 | HealthCells control which genes they express by multiple mechanisms, one of which is the direct modification of DNA with small molecules. Methylation of genes effectively silences them, and…
Cat's out of the bag: PUMA contributes to ulcerative colitis
— 2 Apr 2011 11:37 | HealthUlcerative colitis (UC) is an inflammatory bowel disease thought to be related to aberrant activation of the immune system in the intestine. Recent research has also suggested that…
New mouse model explains common paediatric brain tumour
— 14 Mar 2011 20:39 | HealthPilocytic astrocytoma (PA) is the most common paediatric brain tumour, and there are few medical therapies available to those patients for whom surgery is not curative. However, it…
Using a molecular switch to turn on cancer vaccines
— 8 Mar 2011 13:20 | HealthThe immune system is capable of recognising tumour growth, and naturally mounts an anti-cancer defence. Dendritic cells (DCs) can take up tumour-derived molecules (antigens) and present…
DREADD-ing your next meal
— 2 Mar 2011 13:35 | HealthIn the face of the growing obesity epidemic, much research has focused on the neuronal control of feeding behaviour. Agouti-related protein (AgRP) neurones express three proteins that…
Common congenital defect a prickly problem for the kidney
— 22 Feb 2011 23:32 | HealthOne of the most common congenital defects in humans - it is detected in approximately 0.5% of foetuses analysed by routine antenatal sonography - is a kidney abnormality known as hydronephrosis.…
Profiling malaria-causing parasites
— 8 Feb 2011 18:21 | HealthThe majority of fatal cases of malaria are caused by infection with the parasite Plasmodium falciparum. Most at risk are young children and women who are pregnant. A team of researchers,…
Possible new approach to treating a life-threatening blood disorder
— 26 Jan 2011 18:37 | HealthThrombotic thrombocytopenic purpura (TTP) is a life-threatening disease of the blood system. The condition is caused by the presence of ultralarge multimers of the protein von Willebrand…
Transforming skin cells into cartilage
— 10 Jan 2011 18:45 | HealthIn this paper, Noriyuki Tsumaki and his team at the Osaka University Graduate School of Medicine, used fibroblasts isolated from adult mouse skin, and expressed proteins used to induce…
Cancer cell survival is not 'miR-ly' dependent on p53
— 10 Jan 2011 18:42 | HealthSquamous cell carcinoma (SCC) is a common type of skin cancer. In this paper, Leif Ellisen and colleagues at Mass General Hospital investigated the p53-related proteins p63 and p73…